Detalhe da pesquisa
1.
Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity.
Cell
; 177(3): 597-607.e9, 2019 04 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-31002796
2.
Differential Effects of Furin Deficiency on Insulin Receptor Processing and Glucose Control in Liver and Pancreatic ß Cells of Mice.
Int J Mol Sci
; 22(12)2021 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-34198511
3.
Phlorizin pretreatment reduces acute renal toxicity in a mouse model for diabetic nephropathy.
J Biol Chem
; 288(38): 27200-27207, 2013 Sep 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-23940028
4.
Loss of hypothalamic Furin affects POMC to proACTH cleavage and feeding behavior in high-fat diet-fed mice.
Mol Metab
; 66: 101627, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36374777
5.
Human loss-of-function variants in the serotonin 2C receptor associated with obesity and maladaptive behavior.
Nat Med
; 28(12): 2537-2546, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36536256
6.
Loss of Furin in ß-Cells Induces an mTORC1-ATF4 Anabolic Pathway That Leads to ß-Cell Dysfunction.
Diabetes
; 70(2): 492-503, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33277337
7.
Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation.
Cell Rep
; 34(12): 108862, 2021 03 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-33761344
8.
Human BDNF/TrkB variants impair hippocampal synaptogenesis and associate with neurobehavioural abnormalities.
Sci Rep
; 10(1): 9028, 2020 06 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32493978
9.
The AlfpCre mouse revisited: evidence for liver steatosis related to growth hormone deficiency.
Hepatology
; 58(6): 2209-10, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-23703642
10.
Transgenic Artifacts Caused by Passenger Human Growth Hormone.
Trends Endocrinol Metab
; 29(10): 670-674, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29921469
11.
Quantitative mass spectrometry for human melanocortin peptides in vitro and in vivo suggests prominent roles for ß-MSH and desacetyl α-MSH in energy homeostasis.
Mol Metab
; 17: 82-97, 2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30201275
12.
Endosome to trans-Golgi network transport of Proprotein Convertase 7 is mediated by a cluster of basic amino acids and palmitoylated cysteines.
Eur J Cell Biol
; 96(5): 432-439, 2017 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-28413120
13.
Metabolic and Behavioural Phenotypes in Nestin-Cre Mice Are Caused by Hypothalamic Expression of Human Growth Hormone.
PLoS One
; 10(8): e0135502, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26275221
14.
Liver-Specific Inactivation of the Proprotein Convertase FURIN Leads to Increased Hepatocellular Carcinoma Growth.
Biomed Res Int
; 2015: 148651, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26167473
15.
Impaired islet function in commonly used transgenic mouse lines due to human growth hormone minigene expression.
Cell Metab
; 20(6): 979-90, 2014 Dec 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-25470546
16.
Human Growth Hormone in Transgenesis: A Growing Problem?
Diabetes
; 64(11): 3648-50, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26494217